Defend applications and data before your server is built with the new HPE Trusted Supply Chain offering.
Supporting additional second generation Intel® Xeon® Scalable processor family offerings.
Increased Single-Width GPU Density with up to 7 NVIDIA Tesla T4 16GB Computational Accelerators or 7 Xilinx Alveo U50 Accelerators supported in a standard-depth 2U rack form factor
Networking Choice (NC) server models provide greater flexibility in the primary networking selection.
HPE Persistent Memory offers the flexibility to deploy as dense memory or fast storage using Intel® Optane™ DC Persistent Memory and enables per-socket memory capacity of up to 3.0 TB. 
iLO 5 security enhancements: Server Configuration Lock, iLO Security Dashboard and Workload Performance Advisor. HPE InfoSight provides cloud-based analytics to predict and prevent issues proactively.
Defend Applications and Data Before Your Server is Built with HPE Trusted Supply Chain
Built in secure HPE facilities to the most stringent Country of Origin USA and conformance requirements, HPE Trusted Supply Chain servers are inspected to be free from malicious microcode and counterfeit parts, safeguarding it against cyber-exploits throughout its life cycle.
With hardened security built in, HPE Trusted Supply Chain hardens the protections designed into select HPE products with unrivaled supply chain visibility and standards compliance providing a 360-degree view and mitigation plan for current and emerging cyber-threats.
Allied to ensure authenticity, HPE Trusted Supply Chain doubles down on your protection with vetted HPE employees assigned to the product build to manage the product manufacturing process that adheres to the strictest sourcing, inspection and traceability standards.
A new first line of defense against cyber-attackers with select servers built to the world’s toughest security standards in secured facilities, bringing together security, processes and people to deliver protection for your most sensitive applications and data even before your server is built.
Learn more about HPE Trusted Supply Chain
World-Class Performance featuring Enhanced Compute Density
Leveraging HPE's most popular 2U rackmount server, fitting standard depth racks, customers can benefit from one of the densest Accelerator/GPU platforms with an extensive set of Accelerator options, enabling diverse cloud workload performance and optimization of AI and deep learning experiences.
Supported on the ProLiant DL380, the NVIDIA T4 GPU is ideal for Deep learning, Inferencing, Machine Learning, HPC, Rendering, VDI, Virtual Workstations and combinations thereof for mixed workloads - maximizing utilization of data center resources and lowering TCO.
The ProLiant DL380 now features significantly enhanced GPU density, expanding support from five to seven Full-Height, Half-Length, Single-Width Accelerators/GPUs; or up to six in a balanced configuration with additional PCIe expansion via the tertiary riser.
Flexible Design Making Your Investment Expand As Your Business Needs Grow
In conjunction with the embedded SATA HPE Dynamic Smart Array S100i Controller for boot, data and media needs, the redesigned HPE Smart Array Controllers allow you the flexibility to choose the optimal 12 Gb/s controller most suited to your environment, and operate in both SAS and HBA mode.
Supporting a wide range of operating environments from Azure to Docker to ClearOS in addition to traditional operating systems.
HPE Persistent Memory works with DRAM to provide fast, high capacity, cost effective memory and storage to transform big data workloads and analytics by enabling data to be stored, moved, and processed quickly.
Adapting and growing to changing business needs, Networking Choice (NC) server models provide flexibility in the primary networking choice while Embedded LOM server models offer an embedded 4x1GbE by default; both provide network options (1GbE to 100GbE) via HPE FlexibleLOM or PCIe standup adapters.
The HPE ProLiant DL380 Gen10 server has an adaptable chassis, including new Hewlett Packard Enterprise modular drive bay configuration options with up to 30 SFF, up to 19 LFF or up to 20 NVMe drive options along with support for up to three double wide GPU options.
Industry Leading Services and Ease of Deployment
A suite of embedded and downloadable tools is available for server lifecycle management including Unified Extensible Firmware Interface (UEFI), Intelligent Provisioning; HPE iLO 5 to monitor and manage; HPE iLO Amplifier Pack, Smart Update Manager (SUM), and Service Pack for ProLiant (SPP).
Hewlett Packard Enterprise IT investment solutions help you transform to a digital business with IT economics that align to your business goals.
The HPE ProLiant DL380 Gen10 server comes with a complete set of HPE Technology Services, delivering confidence, reducing risk, and helping customers realize agility and stability.
HPE Pointnext Services simplifies all stages of the IT journey. Advisory and Transformation Services professionals understand customer challenges and design an optimal solution. Professional Services enable rapid deployment of solutions and Operational Services provide ongoing support.
- Processor Name
- Processor number
- 1 or 2
- Processor cache
- 8.25 - 38.50 MB L3, depending on processor model
- Processor core available
- 4 to 28 core, depending on model
- Processor speed
- 3.9 GHz, maximum depending on processor
- Memory slots
- 24 DIMM slots
- Maximum memory
- 3.0 TB with 128 GB DDR4, depending on processor model
- 6.0 TB with HPE 512GB 2666 Persistent Memory Kit, depending on processor model
- Memory type
- HPE DDR4 Smart Memory with optional Intel Optane Persistent Memory for HPE, depending on processor model selected. Intel Optane Persistent Memory for HPE only supported on select 2nd Generation Intel Scalable Series Processors, to include: 82xx, 62xxR, 62xx, 52xxR, 52xx series processors, and the 4215R and 4215 processors.
- Memory, standard
- 3.0 TB (24 X 128 GB) LRDIMM
- 6.0 TB (12 X 512 GB) Persistent Memory
- Network controller
- HPE 1 Gb 331i Ethernet adapter 4-ports per controller and/or optional HPE FlexibleLOM, depending on model
- Storage controller
- 1 HPE Smart Array S100i and/or 1 HPE Smart Array P408i-a and/or 1 HPE Smart Array P816i-a and/or 1 HPE Smart Array E208i-a, depending on model
- Expansion slots
- 8, for detailed descriptions reference the QuickSpecs
- System fan features
- Hot-plug redundant fans, standard
- Form factor
- Infrastructure management
- HPE iLO Standard with Intelligent Provisioning (embedded), HPE OneView Standard (requires download) (standard) HPE iLO Advanced, and HPE OneView Advanced (optional
- requires licenses)
- Product Dimensions (metric)
- 44.55 x 73.03 x 8.74 cm
- Product Dimensions (imperial)
- 17.54 x 28.75 x 3.44 in
- 14.76 kg
- 32.6 lb